Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway.

@article{Chen2013AntiangiogenicEO,
  title={Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-$\kappa$B-mediated VEGF signaling pathway.},
  author={Hui Chen and Jianhong Zhang and Jiang Luo and Fuji Lai and Zhaohong Wang and Hong-fei Tong and Dian Lu and Heqi Bu and Riyuan Zhang and Shengzhang Lin},
  journal={Oncology reports},
  year={2013},
  volume={30 2},
  pages={
          589-95
        }
}
Oxymatrine, the main alkaloid component in the traditional Chinese herbal medicine Sophora japonica (Sophora flavescens Ait), has been reported to have antitumor properties. However, the mechanisms of action in human pancreatic cancer are not well established to date. In the present study, we investigated the antiangiogenic effects of oxymatrine on human pancreatic cancer as well as the possible mechanisms involved. The results of the cell viability assay showed that treatment of PANC-1… Expand
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