Antiangiogenic effect of angiotensin II type 2 receptor in ischemia-induced angiogenesis in mice hindlimb.

@article{Silvestre2002AntiangiogenicEO,
  title={Antiangiogenic effect of angiotensin II type 2 receptor in ischemia-induced angiogenesis in mice hindlimb.},
  author={Jean-S{\'e}bastien Silvestre and Radia Tamarat and Takaaki Senbonmatsu and Toshihiro Icchiki and Teni G. Ebrahimian and Marc Iglarz and Sandrine Besnard and Micheline Duriez and Tadashi Inagami and Bernard I L{\'e}vy},
  journal={Circulation research},
  year={2002},
  volume={90 10},
  pages={1072-9}
}
This study examined the potential role of angiotensin type 2 (AT(2)) receptor on angiogenesis in a model of surgically induced hindlimb ischemia. Ischemia was produced by femoral artery ligature in both wild-type and AT(2) gene-deleted mice (Agtr2(-)/Y). After 28 days, angiogenesis was quantitated by microangiography, capillary density measurement, and laser Doppler perfusion imaging. Protein levels of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), Bax, and… CONTINUE READING