Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma.

@article{Pierpaoli2015AntiangiogenicAA,
  title={Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma.},
  author={E. Pierpaoli and E. Damiani and F. Orlando and G. Lucarini and Beatrice Bartozzi and P. Lombardi and C. Salvatore and Cristina Geroni and A. Donati and M. Provinciali},
  journal={Carcinogenesis},
  year={2015},
  volume={36 10},
  pages={
          1169-79
        }
}
  • E. Pierpaoli, E. Damiani, +7 authors M. Provinciali
  • Published 2015
  • Biology, Medicine
  • Carcinogenesis
  • Berberine (BBR) is a natural isoquinoline alkaloid with proven antiangiogenic and anticancer activities. We recently demonstrated that BBR and its synthetic derivative 13-(4-chlorophenylethyl)berberine iodide, NAX014, exert antiproliferative activity against HER2-overexpressing breast cancer cells, inducing apoptosis, modulating the expression of cell cycle checkpoint molecules involved in cell senescence, and reducing both HER2 expression and phosphorylation on tumor cells. In this study, we… CONTINUE READING
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