Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

@article{Matsumoto2011AntiangiogenicAS,
  title={Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.},
  author={Shingo Matsumoto and Sonny Batra and Keita Saito and Hironobu Yasui and Rajani Choudhuri and Chandramouli V R Gadisetti and Sankaran Subramanian and Nallathamby Devasahayam and Jeeva P. Munasinghe and James B. Mitchell and Murali Cherukuri Krishna},
  journal={Cancer research},
  year={2011},
  volume={71 20},
  pages={6350-9}
}
Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathways. Angiogenesis inhibitors have been shown to transiently normalize the tumor vasculatures and enhance tumor response to treatments. However, the effect of antiangiogenic therapy… CONTINUE READING

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