Antiangiogenic activity of xanthomicrol and calycopterin, two polymethoxylated hydroxyflavones in both in vitro and ex vivo models.

@article{Abbaszadeh2014AntiangiogenicAO,
  title={Antiangiogenic activity of xanthomicrol and calycopterin, two polymethoxylated hydroxyflavones in both in vitro and ex vivo models.},
  author={Hassan Abbaszadeh and Soltan Ahmad Ebrahimi and Maziar Mohammad Akhavan},
  journal={Phytotherapy research : PTR},
  year={2014},
  volume={28 11},
  pages={1661-70}
}
Our previous studies had shown xanthomicrol and calycopterin, two plant-derived flavonoids, to have selective antiproliferative activity against some malignant cell lines. The present study is focused on the investigation of antiangiogenic potential of these two flavonoids, using in vitro and ex vivo models. Xanthomicrol and calycopterin were found to have potent inhibitory effects on microvessel outgrowth in the rat aortic ring assay. Xanthomicrol was able to completely block microvessel… CONTINUE READING