Antiangiogenic activity of the MDM2 antagonist nutlin-3.

  title={Antiangiogenic activity of the MDM2 antagonist nutlin-3.},
  author={Paola Secchiero and Federica Corallini and Arianna Gonelli and Raffaella Dell'eva and Marco Vitale and Silvano Capitani and Adriana Albini and Giorgio Zauli},
  journal={Circulation research},
  volume={100 1},
Nutlin-3, a nongenotoxic activator of the p53 pathway, dose-dependently (range 0.1 to 10 micromol/L) inhibited the formation of capillaries in an in vivo matrigel assay, as well as the formation of capillary-like structures in an in vitro coculture system composed of endothelial cells surrounded by fibroblasts. In contrast to the chemotherapeutic agent doxorubicin, nutlin-3 showed no induction of apoptosis in vitro either in the cocultures or in isolated vascular endothelial cells, even when… CONTINUE READING
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