Antiangiogenic activity of indole-3-carbinol in endothelial cells stimulated with activated macrophages.

Abstract

The effect of indole-3-carbinol (I3C), a major indolic metabolite in cruciferous vegetables, on lipopolysaccharide (LPS)-activated macrophage-induced tube formation and its associated factors in endothelial EA hy926 cells was investigated. LPS significantly enhanced the capillary-like structure of endothelial cells (ECs) co-cultured with macrophages, but no… (More)
DOI: 10.1016/j.foodchem.2012.02.185

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