Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge.

@article{RodrguezNieto2001AntiangiogenicAO,
  title={Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge.},
  author={Salvador Rodr{\'i}guez-Nieto and Mauricio Gonz{\'a}lez-Iriarte and Rita Carmona and Ramon Mu{\~n}oz-Ch{\'a}puli and Miguel {\'A}ngel Medina and Ana R Quesada},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={16 2},
  pages={
          261-3
        }
}
(+)-aeroplysinin-1, an antibacterial brominated compound produced by certain sponges, was selected during a blind high-throughput screening for new potential antiangiogenic compounds obtained from marine organisms. In a variety of experimental systems, representing the sequential events of the angiogenic process, aeroplysinin-1 treatment of endothelial cells resulted in strong inhibitory effects. Aeroplysinin-1 inhibited the growth of endothelial cells in culture and induced endothelial cell… CONTINUE READING

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