Antiangiogenic Effect of Deguelin on Choroidal Neovascularization

@article{Kim2008AntiangiogenicEO,
  title={Antiangiogenic Effect of Deguelin on Choroidal Neovascularization},
  author={Jeong Hun Kim and Jin Hyoung Kim and Young Suk Yu and Kyu Hyung Park and Hye Jin Kang and Ho-Yyoung Lee and Kyu-Won Kim},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={324},
  pages={643 - 647}
}
Age-related macular degeneration is the leading cause of blindness in the elderly. Choroidal neovascularization (CNV) leads to severe vision loss in patients of age-related macular degeneration. Previously, we have demonstrated that deguelin, isolated from plants in the Mundulea sericea family, is a chemopreventive agent. This study evaluates the antiangiogenic effect of deguelin on CNV. The toxicity of deguelin was evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide… 
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