Antiangiogenic Activity of 2-Deoxy-D-Glucose

@inproceedings{Merchn2010AntiangiogenicAO,
  title={Antiangiogenic Activity of 2-Deoxy-D-Glucose},
  author={J. C. Rama Merch{\'a}n and Krisztina Szal{\'o}kin{\'e} Kov{\'a}cs and Jaclyn W. Railsback and Metin Kurtoğlu and Yuqi Jing and Yolanda Castillo Pi{\~n}a and Ningguo Gao and Timothy Garrett Murray and Mark A. Lehrman and Theodore J. Lampidis},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY/PRINCIPAL FINDINGS In cell culture, 2-DG inhibited EC growth, induced cytotoxicity, blocked migration… CONTINUE READING

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