Antianginal effects of intravenous nitroglycerin over 24 hours.

  title={Antianginal effects of intravenous nitroglycerin over 24 hours.},
  author={D Zimrin and Nathaniel Reichek and K T Bogin and Gerard P. Aurigemma and Patricia Douglas and Barbara A Berko and H. L. Fung},
  volume={77 6},
To determine the constancy of hemodynamic and antianginal effects of the constant infusion of intravenous nitroglycerin (NTG) and their relationship to infusion rate and plasma NTG concentration, we administered maximal tolerated doses of intravenous NTG (range 10 to 120 micrograms/min, mean = 52 +/- 33 micrograms/min) and placebo to 10 patients with chronic stable angina for 25 hr each in a randomized, double-blind fashion. Sublingual NTG (0.4 mg) was given at 24.5 hr of infusion as a positive… CONTINUE READING