Antiandrogens: Clinical applications

  title={Antiandrogens: Clinical applications},
  author={Francesco Sciarra and Vincenzo Toscano and Giuseppe Concolino and Franco Di Silverio},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours
Casodex is very active in various models of hormone-dependent carcinomas, however, the limited duration of action in prostatic tumours and the incomplete growth inhibition in mammary tumours suggest that it should be used only combination with other endocrine therapies.
The use of flutamide in the management of hirsutism
The decrease in circulating androgen levels observed during treatment suggests that flutamide can also modulate androgen production and /or metabolism.
Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.
The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamia is a safe, well-tolerated and effective alternative in treatment.
Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment
  • H. Bossche
  • Chemistry, Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
  • 1992
Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne.
Six months treatment with 100 mg spironolactone compared with placebo was associated with a statistically significant subjective improvement in hair growth and a decrease in Ferriman-Galwey scores, and the effectiveness of treatment for acne vulgaris cannot be determined.
Treatment of hyperandrogenism in women
Therapy using antiandrogens contributes to avoiding the development of polycystic ovary syndrome, reducing the increased risk of endometrial cancer in cases of hyperandrogenemia and avoiding the associated cardiovascular complications of hyper androgenemia.


[Therapy of androgenization symptoms: double blind study of an antiandrogen preparation (SH B 209 AB) against neogynon (author's transl)].
It was shown that the therapy with the combination preparation containing cyproterone acetate was distinctly more successful in cases of acne and seborrhoea: not only acne in its various locations but also all forms of sebor rhoea were more favourably influenced by the trial preparation.
New therapeutic approach to the hirsute patient.
The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-androgen “Cyproterone Acetate” for Therapy
It was concluded that in all patients studied hirsutism was associated with elevated testosterone readings and attempts were performed to locate the source of androgen excess using dexamethazone and an estrogen-progestogen mixture in the form of an oral contraceptive pill respectively.
Interactions of an anti-androgen (cyproterone acetate) with the androgen receptor system and its biological action in the rat ventral prostate.
The steroid levels in plasma (testosterone, DHT, 3 alpha-diol) were in the range of untreated adult animals and not significantly influenced by the CyAc treatment.
Inhibitory effect of bromocriptine treatment on luteinizing hormone secretion in polycystic ovary syndrome.
Results indicate a dopaminergic component in the control of LH release in PCO patients, independent of the mechanism governing PRL secretion, and since bromocriptine reduced LH secretion, it may be useful for the management of this condition.
Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism
Spironolactone administration appears promising in the therapy of female hirsutism, and acne and seborrhoea improved concomitantly.
Acne: double blind clinical and laboratory trial of tetracycline, oestrogen-cyproterone acetate, and combined treatment.
Adding antibiotics offers no advantage over using oestrogen-cyproterone on its own, although in this study the combination was more effective than tetracycline alone at six months.