Antiandrogens: Clinical applications

@article{Sciarra1990AntiandrogensCA,
  title={Antiandrogens: Clinical applications},
  author={Francesco Sciarra and Vincenzo Toscano and Giuseppe Concolino and Franco Di Silverio},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1990},
  volume={37},
  pages={349-362}
}
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours
TLDR
Casodex is very active in various models of hormone-dependent carcinomas, however, the limited duration of action in prostatic tumours and the incomplete growth inhibition in mammary tumours suggest that it should be used only combination with other endocrine therapies.
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TLDR
The decrease in circulating androgen levels observed during treatment suggests that flutamide can also modulate androgen production and /or metabolism.
Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.
TLDR
The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamia is a safe, well-tolerated and effective alternative in treatment.
Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment
  • H. Bossche
  • Chemistry, Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
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Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne.
TLDR
Six months treatment with 100 mg spironolactone compared with placebo was associated with a statistically significant subjective improvement in hair growth and a decrease in Ferriman-Galwey scores, and the effectiveness of treatment for acne vulgaris cannot be determined.
Treatment of hyperandrogenism in women
TLDR
Therapy using antiandrogens contributes to avoiding the development of polycystic ovary syndrome, reducing the increased risk of endometrial cancer in cases of hyperandrogenemia and avoiding the associated cardiovascular complications of hyper androgenemia.
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