Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy Poecilia reticulata.

  title={Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy Poecilia reticulata.},
  author={Erik Baatrup and Mette Junge},
  journal={Environmental Health Perspectives},
  pages={1063 - 1070}
Environmental contaminants have been identified as endocrine disruptors through their antiandrogenic activity. Thus, as androgen receptor antagonists, the fungicide vinclozolin and the principal DDT metabolite p,p'-DDE have been demonstrated to induce demasculinization in rats. Whether this is also the case in fish remains to be demonstrated. For a period of 30 days, groups of adult male guppies were exposed to vinclozolin, p,p'-DDE, or the therapeutic antiandrogen flutamide (used as positive… CONTINUE READING

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