Antiandrogen treatments in locally advanced prostate cancer: are they all the same?

@article{Gillatt2006AntiandrogenTI,
  title={Antiandrogen treatments in locally advanced prostate cancer: are they all the same?},
  author={David Gillatt},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2006},
  volume={132},
  pages={17-26}
}
  • D. Gillatt
  • Published 15 July 2006
  • Medicine
  • Journal of Cancer Research and Clinical Oncology
PurposeThe objectives are to review the published literature and to evaluate the weight of evidence for clinical effectiveness, safety, and tolerability of the currently available antiandrogens in the treatment of locally advanced prostate cancer. This article covers efficacy as monotherapy relative to castration and as adjuvant to radiotherapy and radical prostatectomy as well as adverse-effect and quality-of-life data.MethodsThe current literature from online databases between 1986 and the… Expand
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TLDR
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Current data are inadequate to draw conclusions on the comparative efficacy of flutamide and castration, while nilutamide is not licensed for monotherapy, and bicalutamide has a more favourable side‐effect profile than the other antiandrogens and is more likely to promote compliance. Expand
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