Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain.

@article{Yao2011AntiallodynicEO,
  title={Antiallodynic effects of propentofylline Elicited by interrupting spinal glial function in a rat model of bone cancer pain.},
  author={Ming Yao and Xiang-yang Chang and Yu-xia Chu and Jianping Yang and Li-na Wang and Hao-qiang Cao and Ming-juan Liu and Qi-nian Xu},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 11},
  pages={1877-86}
}
The activation of microglia and astrocytes in the spinal cord is involved in the progress of cancer pain. Propentofylline (PPF), a glial modulating agent, alleviates pain hypersensitivity in neuropathic pain models. The present study investigated the potential roles of PPF in a preclinical rat model of bone caner pain established by inoculating Walker 256 cells into the left tibia. At day 9 postinoculation, single administration of PPF (10 μg/10 μl, i.t.) significantly but transiently… CONTINUE READING