Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation.

@article{Suzuki2008AntiallodynicAA,
  title={Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation.},
  author={Takahiro Suzuki and Kazuyoshi Ueta and Shinji Tamagaki and Takashi Mashimo},
  journal={Anesthesia and analgesia},
  year={2008},
  volume={106 4},
  pages={1309-15, table of contents}
}
BACKGROUND The antidepressant, milnacipran, has been reported to have antinociceptive, antiallodynic, and antihyperalgesic effects. In this study, we examined the mechanisms of the antiallodynic and antihyperalgesic effects of milnacipran in a model of neuropathic pain induced by spinal nerve ligation in mice. METHODS The fifth left lumbar nerve of male C57BL6 mice was tightly ligated. Withdrawal threshold to tactile stimulation and withdrawal latency to heat stimulation in the injured or… CONTINUE READING
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