Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF‐&agr; and CXCL‐1
@article{Brito2018AntiallodynicAO, title={Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF‐\&agr; and CXCL‐1}, author={Ana Mercy S. Brito and Adriana Martins Godin and Paulo S{\'e}rgio A. Augusto and Raquel R. Menezes and Ivo S. F. Melo and Marcela M.G.B. Dutra and Sarah O.A.M. Costa and Franciele A. Goulart and Felipe Fernandes Rodrigues and Marcela Isis Morais and Renes Resende Machado and M{\'a}rcio de Matos Coelho}, journal={European Journal of Pharmacology}, year={2018}, volume={818}, pages={17–25} }
13 Citations
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The results indicate that the clindamycin’s immunomodulatory effects may contribute to a pharmacological potential beyond its antibiotic property, and are associated with reduced production of TNF-α and CXCL-1 and activation of opioidergic mechanisms.
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- Biology, MedicineEuropean journal of pharmacology
- 2018
RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice
- Biology, MedicineInflammopharmacology
- 2022
The results of the present study demonstrate that RI75, a synthetic curcumin analogue, exhibits antiallodynic and antiedematogenic activities.
RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice
- Biology, MedicineInflammopharmacology
- 2022
The results of the present study demonstrate that RI75, a synthetic curcumin analogue, exhibits antiallodynic and antiedematogenic activities.
Potential Impact of Ginsenoside Rg1 on Treatment of Paclitaxel-Induced Neuropathic Pain by TNF-α Inhibitory Action
- Biology, Medicine
- 2020
Treatment of GRg and pregabalin ameliorated the chemotherapeutic agent i.e., PT associated pain response with the control of biomarkers changes like superoxide anion, myeloperoxidase, and TNF-α protein levels and histopathological changes.
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
- MedicineDrug research
- 2019
Evaluating the possible involvement of the nitridergic pathway due to L-NAME and the opioidergic route by NTX in the antinoception induced by NSAIDs validated that the NSAIDs administered alone or in combinations produce antinociception in which other mechanisms of action must be added to the simple inhibition of COXs.
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- ChemistryJournal of Drug Delivery and Therapeutics
- 2018
An attempt is made to explore the complete information of Papaver somniferum including its phytochemistry and pharmacology including its tetrahydrobenzylisoquinolinederived classes.
A narrative review of Siddha polyherbal formulation: Amurthathi chooranam
- MedicineJournal of Research in Siddha Medicine
- 2021
Introduction: Early detection of kidney disease care and management helps prevent morbidity and mortality and improves cost-effectiveness and sustainability. Kidney-related diseases continue to…
A Computational Evidence of the Intermolecular Hydrogen Bonding in Leflunomide: Chemical Shielding Tensors
- ChemistrySSRN Electronic Journal
- 2022
Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice.
- ChemistryBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2020
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