Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury

@inproceedings{Suzuki2012AntiallodynicEO,
  title={Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury},
  author={Yasuyuki Suzuki and Hiromasa Mitsuhata and Mitsutoshi Yuzurihara and Yoshio Kase},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2012}
}
Yokukansan, one of the traditional Japanese herbal medicines, ameliorated neuropathic pain symptoms in patients. In this study, we investigated the effects of yokukansan on neuropathic pain in chronic constriction injury (CCI) model. Oral administration of yokukansan significantly inhibited mechanical and cold allodynia in the von Frey hair or acetone test, respectively. In comparison, amitriptyline, a tricyclic antidepressant, demonstrated moderate, but not significant, antiallodynic effects… CONTINUE READING
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