Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae).

@article{Daikonya2004AntiallergicAF,
  title={Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae).},
  author={Akihiro Daikonya and Shigeki Katsuki and Susumu Kitanaka},
  journal={Chemical \& pharmaceutical bulletin},
  year={2004},
  volume={52 11},
  pages={
          1326-9
        }
}
Three novel chalcone derivatives, mallotophilippens C (1), D (2) and E (3) were isolated from the fruits of Mallotus philippinensis MUELL. ARG. These compounds were identified, using chemical and spectral data, as 1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-(4-hydroxy-phenyl)-propenone, 3-(3,4-dihydroxy-phenyl)-1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-propenone and 1-[5,7-dihydroxy-2-methyl-6-(3-methyl-but-2-enyl)-2-(4… Expand
Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata
TLDR
Three new C-methylated and isoprenylated chalcone derivatives, dentichalcones A–C, together with six known compounds, were isolated from the twigs and leaves of Macaranga denticulata and showed inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) in vitro. Expand
Anti-tuberculosis Compounds from Mallotus philippinensis
Bioassay-directed fractionation of the organic extract of Mallotus philippinensis gave five compounds (1-5), the most active of which against Mycobacterium tuberculosis was a new compound,Expand
Polyphenols from Sophora yunnanensis, and their inhibitory effects on nitric oxide production.
A new flavonoid, (2R,3R)-3,7,4'-trihydroxy-3',5'-dimethoxyflavanone, named sophorayunnanol (1), together with eight known polyphenols (2-9), were isolated from the roots of Sophora yunnanensis C.Y.MAExpand
Novel, Complex Flavonoids from Mallotus philippensis (Kamala Tree)
One new flavanone, 4′-hydroxyisorottlerin (2), and two new chalcone derivatives, kamalachalcones C (3) and D (4), were isolated from Mallotus philippensis (kamala tree). The largest compound (4; MrExpand
Prenylflavones from Psoralea corylifolia Inhibit Nitric Oxide Synthase Expression through the Inhibition of I-κB-α Degradation in Activated Microglial Cells
The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous systemExpand
Concise Total Synthesis of Biologically Interesting Prenylated Chalcone Natural Products : 4'-O-Methylxanthohumol, Xanthohumol E, and Sericone
(0.66 g, 2.8 mmol) and 3-methyl-2-butenal (0.47 g, 5.6mmol) in methylene chloride (20 mL) was added ethylene-diamine diacetate (0.10 g, 0.6 mmol) at room temperature.The reaction mixture was stirredExpand
Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells.
TLDR
Among the 18 synthesized chalcone derivatives, compound 2f exhibited the highest anti-inflammatory activity by inhibition of nitric oxide concentration in LPS-induced RAW264, and docking studies suggested the inhibition of IKKβ as a mechanism of action and highlighted the importance of 2f hydrophobic interactions. Expand
Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica.
TLDR
This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation. Expand
Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities.
TLDR
This review focuses on the anti-inflammatory effects of chalcones, caused by their inhibitory action primarily against the activities and expressions of four key inflammatory mediators viz., cyclooxygenase, prostaglandin E2, inducible NO synthase, and nuclear factor κB. Expand
Review: The potential of chalcones as a source of drugs
TLDR
This review provides a comprehensive analysis of the source plants, chemistry, structure-activity, pharmacological reports of chalcone and derivatives isolated and identified from plants. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Anti-allergic agents from natural sources (4): anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae).
TLDR
Results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects. Expand
Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects.
TLDR
Six new sesquiterpene coumarin derivatives were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line. Expand
Inhibitory effects of hydrolyzable tannins from Melastoma dodecandrum Lour. on nitric oxide production by a murine macrophage-like cell line, RAW264.7, activated with lipopolysaccharide and interferon-gamma.
TLDR
The results suggest that MDL has the pharmacological ability to suppress NO production by activated macrophages and that the hydrolyzable tannins have major inhibitory activities. Expand
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.
TLDR
L-Arginine is required for the activation of macrophages to the bactericidal/tumoricidal state and suggests that nitric oxide is serving as an intracellular signal for this activation process in a manner similar to that very recently observed in endothelial cells, where nitrics oxide leads to vascular smooth muscle relaxation. Expand
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
TLDR
The results indicate that increased synthesis of prostaglandins and thromboxanes in lipopolysaccharide-stimulated macrophages results from selective expression of COX-2, a newly discovered mitogen-inducible cyclooxygenase encoded by a 4-kilobase mRNA. Expand
Dimeric chalcone derivatives from Mallotus philippensis
Two new chalcone derivatives with a unique ring system caused by dimerization between a dimethylchromene ring and a phenoxyl group, were isolated from kamala (Mallotus philippensis). The structuresExpand
Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages.
TLDR
Evidence is provided that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium. Expand
Involvement of inflammatory mediators in macrophage antitumor activity
TLDR
This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role and the roles of TNF‐α and PGE2 in links between inflammatory and antitumor functions of Macrophages. Expand
Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase.
TLDR
Two selective inducible nitric oxide synthase inhibitors, aminoguanidine and N-iminoethyl-L-lysine, suppressed the increase in plasma nitrite levels and joint inflammation associated with adjuvant-induced arthritis in a dose-dependent manner. Expand
Elevated nitric oxide production in rheumatoid arthritis. Detection using the fasting urinary nitrate:creatinine ratio.
TLDR
Dietary intake of nitrate had no significant influence on the fasting morning urinary nitrate:creatinine ratio in the healthy volunteers, showing that this parameter is a useful indicator of endogenous NO production. Expand
...
1
2
...