Antiallergic/antiasthmatic activity of oligopeptide related to IgE.

  title={Antiallergic/antiasthmatic activity of oligopeptide related to IgE.},
  author={Rajendra Pratap Singh and Avindra Nath and P. P. Gupta and M Shulka and Sunil Kumar Khare and Bijoy Kundu},
  journal={Pharmacological research},
  volume={37 5},
In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335 inhibited the passive cutaneous anaphylaxis (PCA) reactions in rats in a dose-dependent manner (0.5-10 mg kg-1 p.o.) by 47-90%. There was a 70-87% protection of mast cell… CONTINUE READING