Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin.

@article{Filep1991AntiaggregatoryAH,
  title={Antiaggregatory and hypotensive effects of endothelin-1 in beagle dogs: role for prostacyclin.},
  author={J{\'a}nos G. Filep and Ferenc Herm{\'a}n and Bruno Battistini and Pierre Etienne Chabrier and Pierre G. Braquet and Pierre Sirois},
  journal={Journal of cardiovascular pharmacology},
  year={1991},
  volume={17 Suppl 7},
  pages={S216-8}
}
The effects of endothelin-1 (ET-1) on blood pressure and platelet aggregation were studied in anesthetized beagle dogs. Platelet aggregation was monitored in vivo by a filter-loop technique and in vitro by using platelet-rich plasma and whole blood. ET-1 (0.03-0.3 nmol/kg) induced a transient dose-dependent hypotension and inhibited platelet aggregation in… CONTINUE READING