Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart.

@article{Liu2002AntiadrenergicEO,
  title={Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart.},
  author={Qinghang Liu and Polly A. Hofmann},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 4},
  pages={H1314-21}
}
The ability of adenosine A(1) receptors to activate type 2a protein phosphatase (PP2a) and account for antiadrenergic effects was investigated in rat myocardial preparations. We observed that the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA) significantly reduces the isoproterenol-induced increase in left ventricular developed pressure of isolated heats, and this effect is blocked by pretreatment of hearts with the PP2a inhibitor cantharidin. CPA alone or given in conjunction… CONTINUE READING
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