Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program.

@article{Gaya2013AntiadipogenicEO,
  title={Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program.},
  author={Mauro Gaya and Victoria Repetto and Judith Toneatto and Claudia Anesini and Graciela Piwien-Pilipuk and Silvia Moreno},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 6},
  pages={3796-806}
}
BACKGROUND Obesity is a serious health problem all over the world, and inhibition of adipogenesis constitutes one of the therapeutic strategies for its treatment. Carnosic acid (CA), the main bioactive compound of Rosmarinus officinalis extract, inhibits 3T3-L1 preadipocytes differentiation. However, very little is known about the molecular mechanism responsible for its antiadipogenic effect. METHODS We evaluated the effect of CA on the differentiation of 3T3-L1 preadipocytes analyzing the… CONTINUE READING