Anti-ulcer activity of colloidal bismuth subcitrate in Shay-rats.

  title={Anti-ulcer activity of colloidal bismuth subcitrate in Shay-rats.},
  author={U. I. Lavy and P. H. Koekkoek and Kapil Dev Jaitly},
  journal={Archives internationales de pharmacodynamie et de therapie},
  volume={224 2},
The anti-ulcer action of colloidal bismuth subcitrate (CBS) was tested in rats with a ligated pylorus (the Shay preparation). The liquid form used in the clinic displayed a dose-related inhibition of gastric ulceration. the recently developed solid form appeared to be just as effective. On the other hand, non-processed, non-colloidal bismuth salts and the CBS vehicle blank were completely inactive. The anti-ulcer activity of CBS was found to be unrelated to its buffering capacity.