Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

@article{Lennox1989AntiubiquitinII,
  title={Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.},
  author={Graham Lennox and James S. Lowe and Kristie Morrell and M. Landon and Ruth J. Mayer},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1989},
  volume={52 1},
  pages={67-71}
}
Brainstem and cortical Lewy bodies in diffuse Lewy body disease show intense immunoreactivity to antibodies against ubiquitin. Quantitative studies show that the novel neuropathological technique of anti-ubiquitin immunocytochemistry is more than twice as sensitive as conventional haematoxylin and eosin stains in detecting cortical Lewy bodies. Anti-ubiquitin immunocytochemistry should be regarded as the method of choice for the diagnosis and quantification of diffuse Lewy body disease. 

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Cortical Lewy bodies and the spectrum of Lewy body disease

G Lennox, JS Lowe, J Byrne
J Neurol Neurosurg Psychiatry • 1988

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