Anti tumour necrosis factor as risk factor for free perforations in Crohn's disease? A case-control study.

@article{Eshuis2012AntiTN,
  title={Anti tumour necrosis factor as risk factor for free perforations in Crohn's disease? A case-control study.},
  author={Emma J. Eshuis and Gwendolyn H M J Griffioen and Pieter C. F. Stokkers and Dirk Th Ubbink and W. A. Bemelman},
  journal={Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland},
  year={2012},
  volume={14 5},
  pages={578-84}
}
AIM Although the occurrence of intestinal perforation in Crohn's disease (CD) is rare, clinical observation has led to the question whether anti tumour necrosis factor (TNF) treatment is a risk factor for free perforation. The aim of this study was to investigate the possible relation between anti-TNF treatment and occurrence of free perforation, defined as intestinal perforations leading to emergency surgery. METHOD In this case-control study, all emergency operation reports from the period… CONTINUE READING
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