Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells

@article{vanNifterik2011AntitumourEB,
  title={Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells},
  author={Krista A van Nifterik and Jaap van den Berg and Ben J. Slotman and J M van Rijn},
  journal={International Journal of Radiation Biology},
  year={2011},
  volume={87},
  pages={192 - 201}
}
Purpose: To investigate the possible cytotoxic interactions between the chemotherapeutic drug temozolomide (TMZ) and the cyclooxygenase-2 inhibitor meloxicam (MLC) or of both drugs combined with X-rays in three human glioma cell lines (D384, Hs 683 and U251). Materials and methods: Cells were exposed to TMZ (96 hours) and MLC was co-incubated during the last 24 h. Thereafter, cells were irradiated with X-rays and plated for a clonogenic assay. Total cell numbers and the numbers of surviving… 

COX-2 and c-kit expression in canine gliomas.

TLDR
COX-2 inhibitors and c-kit inhibitors may have an anti-angiogenic effect in high-grade gliomas, but would likely be ineffective in low- and medium-grade tumours.

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