Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells

  title={Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells},
  author={Krista A van Nifterik and Jaap van den Berg and Ben J. Slotman and J M van Rijn},
  journal={International Journal of Radiation Biology},
  pages={192 - 201}
Purpose: To investigate the possible cytotoxic interactions between the chemotherapeutic drug temozolomide (TMZ) and the cyclooxygenase-2 inhibitor meloxicam (MLC) or of both drugs combined with X-rays in three human glioma cell lines (D384, Hs 683 and U251). Materials and methods: Cells were exposed to TMZ (96 hours) and MLC was co-incubated during the last 24 h. Thereafter, cells were irradiated with X-rays and plated for a clonogenic assay. Total cell numbers and the numbers of surviving… 

COX-2 and c-kit expression in canine gliomas.

COX-2 inhibitors and c-kit inhibitors may have an anti-angiogenic effect in high-grade gliomas, but would likely be ineffective in low- and medium-grade tumours.



Survival of human glioma cells treated with various combination of temozolomide and X-rays.

Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines.

Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells.

In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations.

Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: Independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration

Effectiveness of COx-2 inhibitors on cell proliferation and radio-enhancement was independent of COX-2 protein expression.

Proliferation and clonal survival of human lung cancer cells treated with fractionated irradiation in combination with paclitaxel.

In vitro and In vivo Radiosensitization Induced by the DNA Methylating Agent Temozolomide

It is suggested that temozolomide can enhance tumor cell radiosensitivity in vitro and in vivo and that this effect involves an inhibition of DNA repair leading to an increase in mitotic catastrophe.

Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells.

A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2.

  • H. PyoH. Choy R. DuBois
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2001
The in vitro and in vivo results suggest that selective COX-2 inhibitors enhance the effect of radiation on tumors that express COZ-2 but not on COx-2-lacking tumors and may have potential as radiosensitizers for treatment of human cancers.

Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.

Combination studies showed synergistic interactions for sulindac sulfide, exisulind, and NDGA with paclitaxel, cisplatin, and 13-cis-retinoic acid, regardless of drug-resistance phenotype, which provides a rationale for chemoprevention and therapeutic studies in patients at risk for, or with, lung cancer.