Anti-tumour activity and bone marrow toxicity of chloroethylnitrosocarbamoyl-amino acid derivatives.

@article{Matthew1992AntitumourAA,
  title={Anti-tumour activity and bone marrow toxicity of chloroethylnitrosocarbamoyl-amino acid derivatives.},
  author={A. J. Matthew and Michael Charles Bibby and John A. Double},
  journal={Anticancer research},
  year={1992},
  volume={12 2},
  pages={361-5}
}
The anti-tumour activity of a series of chloroethylnitrosoureas derived from the amino acids alanine and glycine was examined in 3 transplantable adenocarcinomas of the mouse colon. In addition, bone marrow toxicity was assessed using a spleen colony forming unit assay. A spectrum of differing activity-toxicity patterns was demonstrated. At one extreme CNC… CONTINUE READING