Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent.

@article{Zhao1999AntitumorpromotingAO,
  title={Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent.},
  author={J. Zhao and J. Wang and Y. Chen and R. Agarwal},
  journal={Carcinogenesis},
  year={1999},
  volume={20 9},
  pages={
          1737-45
        }
}
Procyanidins present in grape seeds are known to exert anti-inflammatory, anti-arthritic and anti-allergic activities, prevent skin aging, scavenge oxygen free radicals and inhibit UV radiation-induced peroxidation activity. Since most of these events are associated with the tumor promotion stage of carcinogenesis, these studies suggest that grape seed polyphenols and the procyanidins present therein could be anticarcinogenic and/or anti-tumor-promoting agents. Therefore, we assessed the anti… Expand
A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation.
Study on prevention of two-stage skin carcinogenesis by Hibiscus rosa sinensis extract and the role of its chemical constituent, gentisic acid, in the inhibition of tumour promotion response and oxidative stress in mice
  • S. Sharma, N. Khan, S. Sultana
  • Chemistry, Medicine
  • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2004
ANTICANCER EFFECTS OF GRAPE SEED EXTRACT ON HUMAN CANCER: A REVIEW
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