Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust.

@article{Kim2006AntitumorNF,
  title={Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust.},
  author={Jiyoun E Kim and Laura McKinley and Sudha Natarajan and Gerry L. Bolgos and Javed Ather Siddiqui and Shannon Copeland and Daniel G Remick},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2006},
  volume={36 1},
  pages={122-32}
}
BACKGROUND/AIMS Recent studies documented that sensitization and exposure to cockroach allergens significantly increase children's asthma morbidity as well as severity, especially among inner city children. TNF-alpha has been postulated to be a critical mediator directly contributing to the bronchopulmonary inflammation and airway hyper-responsiveness in asthma. This study investigated whether an anti-TNF-alpha antibody would inhibit pulmonary inflammation and methacholine (Mch) hyper… CONTINUE READING

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