Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic model.

@article{Kadokami2001AntitumorNF,
  title={Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic model.},
  author={Toshiaki Kadokami and Carole S. Frye and Bonnie H. Lemster and Carrie L Wagner and Arthur M Feldman and Charles F McTiernan},
  journal={Circulation},
  year={2001},
  volume={104 10},
  pages={1094-7}
}
BACKGROUND - Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of congestive heart failure. A strain of transgenic mice (TNF1.6) with cardiac-specific overexpression of TNF-alpha develop congestive heart failure. METHODS AND RESULTS To determine the effect of anti-TNF-alpha therapy in this model, we studied 3 groups: TNF1.6 mice treated with saline, wild-type mice treated with saline, and TNF1.6 mice treated with TNF-alpha neutralizing antibody (cV1q) from 6 to 12… CONTINUE READING

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