Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.

  title={Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.},
  author={R. Schiffelers and G. Koning and T. L. T. ten Hagen and M. Fens and A. J. Schraa and A. P. C. A. Janssen and R. J. Kok and G. Molema and G. Storm},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={91 1-2},
  • R. Schiffelers, G. Koning, +6 authors G. Storm
  • Published 2003
  • Chemistry, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
  • Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at angiogenic tumor endothelial cells was developed. Alpha v beta 3-integrins are overexpressed on actively proliferating endothelium and represent a possible target. For this, RGD-peptides with affinity for this integrin were coupled to the distal end of poly(ethylene glycol)-coated long-circulating… CONTINUE READING
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