Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer.

@article{Jeannot2018AntitumorEO,
  title={Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer.},
  author={Victor Jeannot and Cony Gauche and Silvia Mazzaferro and Morgane Couvet and Laetitia Vanwonterghem and Maxime Henry and Chlo{\'e} Didier and Julien Vollaire and V{\'e}ronique Josserand and Jean-Luc Coll and Christophe Schatz and S{\'e}bastien Lecommandoux and Amandine Hurbin},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2018},
  volume={275},
  pages={117-128}
}
Combinations of therapeutic agents could synergistically enhance the response of lung cancer cells. Co-delivery systems capable of transporting chemotherapeutics with different physicochemical properties and with the simultaneous release of drugs remain elusive. Here, we assess the ability of nanoparticles of 30-nm diameter obtained from the self-assembly of hyaluronan-based copolymer targeting CD44 receptors to encapsulate both gefitinib and vorinostat for effective combinational lung cancer… CONTINUE READING
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