Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models.

@article{Su2013AntitumorEO,
  title={Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models.},
  author={Shu Su and Hao Zhou and Meng Xue and Jing-yu Liu and Lei Ding and Meng Cao and Zhen-xian Zhou and Hong-Min Hu and Lixin Wang},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2013},
  volume={14 5},
  pages={3109-16}
}
The majority of hepatocellular carcinoma (HCC) patients have a poor prognosis with current therapies, and new approaches are urgently needed. We have developed a novel therapeutic cancer vaccine platform based on tumor cell derived autophagosomes (DRibbles) for cancer immunotherapy. We here evaluated the effectiveness of DRibbles-pulsed dendritic cell (DC) immunization to induce anti-tumor immunity in BALB/c mouse HCC and humanized HCC mouse models generated by transplantation of human HCC… CONTINUE READING

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References

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Showing 1-10 of 26 references

Autophagy-assisted antigen cross-presentation

Oncoimmunology • 2012
View 1 Excerpt

Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2011
View 4 Excerpts

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