Anti-tumor effects of penfluridol through dysregulation of cholesterol homeostasis.

  title={Anti-tumor effects of penfluridol through dysregulation of cholesterol homeostasis.},
  author={Li Wu and Yan-Yang Liu and Zhi-Xi Li and Qian Zhao and Xia Wang and Yang Yu and Yu-yi Wang and Yiqin Wang and Feng Luo},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  volume={15 1},
BACKGROUND Psychiatric patients appear to be at lower risk of cancer. Some antipsychotic drugs might have inhibitory effects on tumor growth, including penfluridol, a strong agent. To test this, we conducted a study to determine whether penfluridol exerts cytotoxic effects on tumor cells and, if so, to explore its anti-tumor mechanisms. METHODS Growth inhibition of mouse cancer cell lines by penfluridol was determined using the 3- (4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide… CONTINUE READING


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