Corpus ID: 87333720

Anti-tumor effect of panax notoginsenosides combined with cyclophosphamide metronomic chemotherapy

@article{Yan2010AntitumorEO,
  title={Anti-tumor effect of panax notoginsenosides combined with cyclophosphamide metronomic chemotherapy},
  author={Zhu Yan},
  journal={Journal of Beijing University of Traditional Chinese Medicine},
  year={2010}
}
  • Zhu Yan
  • Published 2010
  • Biology
  • Journal of Beijing University of Traditional Chinese Medicine
Objective To observe the anti-tumor effect,anti-angiogenic effect and immune regulation of panax notoginsenosides(PNS) combined with low-dose cyclophosphamide(CTX) metronomic chemotherapy.Methods The model of B16-BL6 melanoma spontaneous metastasis was established by hypodermic injection of B16 cells in the palmula in mice.All mice were randomly divided into the model group,high-dose CTX group(MTD group),low-dose CTX group(metronomic group),PNS group and PNS combined with low-dose CTX group… Expand
1 Citations
Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication.
TLDR
It is suggested that PNS increases the cytotoxicity of cisplatin through enhancement of GJ activity in a dose-dependent manner. Expand