Anti-tumor effect of lentivirus-mediated gene transfer of alphastatin on human glioma.

@article{Guo2011AntitumorEO,
  title={Anti-tumor effect of lentivirus-mediated gene transfer of alphastatin on human glioma.},
  author={Shi-wen Guo and Hong-Min Che and Wen-Zhi Li},
  journal={Cancer science},
  year={2011},
  volume={102 5},
  pages={
          1038-44
        }
}
Alphastatin, an endogenous angiogenesis inhibitor, has recently been used as an anticancer agent in several tumor models. This study was to investigate whether local sustained long-term expression of alphastatin could serve to diminish tumor growth of a human xenograft glioma model. We found that the recombinant alphastatin lentiviruses were able to stably infect HUVECs, and infected HUVECs could sustainably secrete alphastatin, which exhibited potent inhibitory effects on HUVECs migration… CONTINUE READING
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