Anti-tumor effect of adenoviral vector-mediated p53 gene transfer on the growth of canine osteosarcoma xenografts in nude mice.

@article{Kanaya2011AntitumorEO,
  title={Anti-tumor effect of adenoviral vector-mediated p53 gene transfer on the growth of canine osteosarcoma xenografts in nude mice.},
  author={N. Kanaya and M. Yazawa and Y. Goto-Koshino and M. Mochizuki and R. Nishimura and K. Ohno and N. Sasaki and H. Tsujimoto},
  journal={The Journal of veterinary medical science},
  year={2011},
  volume={73 7},
  pages={
          877-83
        }
}
  • N. Kanaya, M. Yazawa, +5 authors H. Tsujimoto
  • Published 2011
  • Chemistry, Medicine
  • The Journal of veterinary medical science
  • We evaluated the anti-tumor effect of adenoviral vector-mediated p53 gene therapy on the growth of canine osteosarcoma xenografts formed in nude mice. Nude mice were subcutaneously transplanted with cells of 2 P53 mutant canine osteosarcoma cell lines, POS and CHOS. The osteosarcoma xenografts were injected with either an adenoviral vector that expresses canine wild-type P53 (AxCA-cp53) or LacZ (AxCA-LacZ). Tumor growth was significantly inhibited in the xenografts injected with AxCA-cp53 in… CONTINUE READING
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