Anti-tumor chemotherapy utilizing peptide-based approaches--apoptotic pathways, kinases, and proteasome as targets.

@article{Mendoza2005AntitumorCU,
  title={Anti-tumor chemotherapy utilizing peptide-based approaches--apoptotic pathways, kinases, and proteasome as targets.},
  author={Francisco Jos{\'e} Colomer Mendoza and Paula S. Espino and Kendra L Cann and Nicolle A Bristow and Kristin McCrea and Marek Los},
  journal={Archivum immunologiae et therapiae experimentalis},
  year={2005},
  volume={53 1},
  pages={47-60}
}
The pharmacological sciences are taking advantage of recent discoveries that have defined the molecular pathways governing apoptosis. These signaling cascades are frequently inactivated or distorted by mutations in cancer cells. Peptides derived from critical interaction, phosphorylation, or cleavage sites are the preferred leads (starting points) for the development of new drugs. In this review we summarize recent peptide-based approaches that target MDM2, p53, NF-kappaB, ErbB2, MAPK, as well… CONTINUE READING

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