Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain

@article{Prins2008AntitumorAA,
  title={Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain},
  author={Robert M. Prins and Chengyi Jenny Shu and Caius G Radu and Dan D. Vo and Haumith Khan-Farooqi and Horacio Soto and M D Yang and Muh-Shi Lin and Stephanie M. Shelly and Owen N Witte and Antoni Ribas and L M Liau},
  journal={Cancer Immunology, Immunotherapy},
  year={2008},
  volume={57},
  pages={1279-1289}
}
It is commonly believed that T cells have difficulty reaching tumors located in the brain due to the presumed “immune privilege” of the central nervous system (CNS). Therefore, we studied the biodistribution and anti-tumor activity of adoptively transferred T cells specific for an endogenous tumor-associated antigen (TAA), gp100, expressed by tumors implanted in the brain. Mice with pre-established intracranial (i.c.) tumors underwent total body irradiation (TBI) to induce transient lymphopenia… CONTINUE READING
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