Anti-tumor activity and cytotoxicity in vitro of novel 4,5-dialkylimidazolium surfactants.

@article{Wang2015AntitumorAA,
  title={Anti-tumor activity and cytotoxicity in vitro of novel 4,5-dialkylimidazolium surfactants.},
  author={Da Yuan Wang and Christian Richter and Andreas R{\"u}hling and Sabine Huewel and Frank Glorius and Hans-Joachim Galla},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={467 4},
  pages={1033-8}
}
Natural monoalkylated imidazolium derivatives exhibit significant anti-tumor activity as well as general cytotoxicity. In the present study, we used a series of newly synthesized imidazolium derivatives bearing two alkyl chains in the backbone of the imidazolium core in 4- and 5-position and either dimethyl- or dibenzyl-substituents at 1- and 3-position. Their anti-tumor activity and cytotoxicity were determined in vitro using the lactate dehydrogenase (LDH) assay. The tumor cell line C6 from… CONTINUE READING
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