Anti-tuberculosis drug combination for controlled oral delivery using 3D printed compartmental dosage forms: From drug product design to in vivo testing.

@article{Genina2017AntituberculosisDC,
  title={Anti-tuberculosis drug combination for controlled oral delivery using 3D printed compartmental dosage forms: From drug product design to in vivo testing.},
  author={Natalja Genina and Johan Peter Boetker and Stefano Colombo and Necati Harmankaya and Jukka Rantanen and Adam Bohr},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2017},
  volume={268},
  pages={
          40-48
        }
}
The design and production of an oral dual-compartmental dosage unit (dcDU) was examined in vitro and in vivo with the purpose of physically isolating and modulating the release profile of an anti-tuberculosis drug combination. Rifampicin (RIF) and isoniazid (ISO) are first line combination drugs for treatment of tuberculosis (TB) that negatively interact with each other upon simultaneous release in acidic environment. The dcDUs were designed in silico by computer aided design (CAD) and… CONTINUE READING
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