Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles.

@article{Kamal2013AntitubercularAP,
  title={Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles.},
  author={Ahmed Kamal and Syed Mohammed Ali Hussaini and Shaikh Faazil and Yedla Poornachandra and G Narender Reddy and Chityal Ganesh Kumar and Vikrant Singh Rajput and Chitra Rani and Rashmi S Sharma and Inshad Ali Khan and Nanubolu Jagadeesh Babu},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 24},
  pages={6842-6}
}
A series of 5-nitrofuran-triazole conjugates were synthesized and evaluated for their antimicrobial activity against both Gram-positive and Gram-negative bacterial strains. All the compounds exhibited promising inhibition towards Gram-positive pathogenic strains, while mild inhibitory effects were observed towards Gram-negative bacterial strains. Some of the compounds 8a, 8b, 8e, 8f, 8h are most active among the series exhibiting MIC value of 1.17 μg/ml against different bacterial strains. The… CONTINUE READING