Anti-transforming growth factor-beta1 antibody improves survival rate following partial hepatectomy in cirrhotic rats.

@article{Ohara2002AntitransformingGF,
  title={Anti-transforming growth factor-beta1 antibody improves survival rate following partial hepatectomy in cirrhotic rats.},
  author={Kazunori Ohara and Mitsuo Kusano},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2002},
  volume={24 2},
  pages={
          174
        }
}
In a cirrhotic liver, regenerative ability is so impaired that massive resection easily complicates postoperative liver dysfunction, which frequently leads to life-threatening multiple-organ failure. Transforming growth factor-beta1 (TGF-beta1) is considered to be a key cytokine regulating both hepatocyte proliferation and matrix expression in fibrosis. Therefore, we investigated the effect of TGF-beta1 inhibitors by using a neutralizing antibody on 70% partial hepatectomy (PHx) in cirrhotic… CONTINUE READING

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Inhibition of

T Nakamura, R Sakata, T Ueno
  • Hepatology Research
  • 2002
VIEW 1 EXCERPT

Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.

  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
  • 1996