Anti-tissue factor pathway inhibitor activity in subjects with antiphospholipid syndrome is associated with increased thrombin generation.

@article{Adams2004AntitissueFP,
  title={Anti-tissue factor pathway inhibitor activity in subjects with antiphospholipid syndrome is associated with increased thrombin generation.},
  author={Murray John Adams and Liza Anne Breckler and Paul Stevens and Jim Y Thom and Ross Baker and Robert Oostryck},
  journal={Haematologica},
  year={2004},
  volume={89 8},
  pages={
          985-90
        }
}
BACKGROUND AND OBJECTIVES Immunoglobulin G (IgG) fractions from subjects with antiphospholipid syndrome (aPS) have previously been demonstrated to have inhibitory activity against tissue factor pathway inhibitor (TFPI). This may contribute to the development of a prothrombotic state by impaired regulation of the tissue factor (TF) pathway. This study investigated the effect that IgG fractions from aPS subjects containing anti-TFPI activity have on in vitro TF-induced thrombin generation… CONTINUE READING

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