Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative.

  title={Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative.},
  author={John L Wallace and W. F. McKnight and Piero del Soldato and Anwar R. Baydoun and Giuseppe Antonio Cirino},
  journal={The Journal of clinical investigation},
  volume={96 6},
Effects of a nitroxybutylester derivative of aspirin (NCX 4215) on platelet aggregation and prostanoid synthesis were compared to the effects of aspirin. NCX 4215 was approximately seven times more potent than aspirin as an inhibitor of thrombin-induced human platelet aggregation in vitro, but did not inhibit platelet thromboxane synthesis or gastric prostaglandin synthesis. NCX 4215 released nitric oxide when incubated in the presence of platelets and increased platelet levels of cGMP within… CONTINUE READING
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