Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

@article{Kao1987AntiterminationOT,
  title={Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product},
  author={S H Kao and Andrew F. Calman and Paul A. Luciw and Boris Matija Peterlin},
  journal={Nature},
  year={1987},
  volume={330},
  pages={489-493}
}
Human immunodeficiency virus-1 (HIV-1) gene expression is controlled by cellular transcription factors and by virally encoded trans-activation proteins of the HIV-1 tat and art/trs genes, which are essential for viral replication1,9–11. Tat trans-activates HIV-1 gene expression by interacting with the trans-acting response element (TAR) located within the HIV-1 long terminal repeat (LTR) (ref. 2). In transient expression assays, tat mediates its effects largely by increasing the steady-state… CONTINUE READING
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