Anti-telomere antibodies in systemic lupus erythematosus: a new ELISA test for anti-DNA with potential pathogenetic implications.

@article{Wallace2000AntitelomereAI,
  title={Anti-telomere antibodies in systemic lupus erythematosus: a new ELISA test for anti-DNA with potential pathogenetic implications.},
  author={Daniel J. Wallace and E M Salonen and Erik Avaniss-Aghajani and Ray Morris and Allan L. Metzger and N Pashinian},
  journal={Lupus},
  year={2000},
  volume={9 5},
  pages={
          328-32
        }
}
BACKGROUND Telomeric hexamer repeats (TTAGGG/CCCTAA)n are highly repetitive sequences of DNA. They cap the termini of eukaryotic chromosomes and stabilize them, preventing degradation or fusion. Anti ds-DNA is one of the most specific tests for systemic lupus erythematosus (SLE). Of related importance, a preliminary report has suggested that anti-telomere antibodies are also highly specific for the presence of SLE. METHODS 220 patients with SLE, 79 with rheumatoid arthritis (RA), 54 with… CONTINUE READING