Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

@article{Yanamandra2017AntitauAA,
  title={Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy},
  author={Kiran Yanamandra and Tirth K. Patel and Hong Jiang and Suzanne Schindler and Jason Daniel Ulrich and Adam L. Boxer and Bruce L. Miller and Diana R. Kerwin and Gilbert Gallardo and Floy R. Stewart and Mary Beth Finn and Nigel J. Cairns and Philip B. Verghese and Ilana Fogelman and Tim West and Joel B. Braunstein and Grace O Robinson and Jennifer L Keyser and Joseph Roh and Stephanie S. Knapik and Yan Feng Hu and David M Holtzman},
  journal={Science Translational Medicine},
  year={2017},
  volume={9}
}
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies. We previously found that administration of an anti-tau antibody to human tau transgenic mice increased the concentration of plasma tau. We further explored the effects of administering an anti-tau antibody on plasma tau. After peripheral… CONTINUE READING
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Anti - tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

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