Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy.

@article{Shirvan2002Antisemaphorin3A,
  title={Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy.},
  author={Anat Shirvan and Michal Kimron and Vered Holdengreber and Ilan Ziv and Yehuda Ben-Shaul and Shlomo Melamed and Eldad Melamed and Ari Barzilai and Arieh Sorin Solomon},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 51},
  pages={49799-807}
}
Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. The mechanisms that mediate the response of the neuronal cells to the axonal injury are still unknown. We have previously shown that semaphorins, axon guidance molecules with repulsive cues, are capable of mediating apoptosis in cultured neuronal cells (Shirvan, A., Ziv, I., Fleminger, G., Shina, R., He, Z., Brudo, I., Melamed, E., and Brazilai, A. (1999) J. Neurochem… CONTINUE READING

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